- We recommend that HIV-positive adults
that require vaccination against diphtheria, tetanus, or polio be
given the parenteral Td/IPV
vaccine in accordance with general indications, and regardless of
CD4 cell count, ART use, and viral load.
- We recommend that individuals who are
or have an uncertain vaccination history receive 3
vaccine doses at 1 month interval, followed by 2 booster doses
after 5 and 10 years; partially vaccinated individuals should
complete the 5-dose vaccine course.
- We recommend that fully vaccinated
individuals (5 doses) receive a booster dose every 10 years if at
risk of exposure, typically through travel.
- We recommend that individuals who may be
occupationally exposed to diphtheria (e.g. laboratory workers) be
tested for diphtheria antibodies 3 months after vaccination to
confirm protective immunity, and be revaccinated if required.
- We recommend that following
a credible or confirmed exposure to diphtheria, HIV-positive
contacts receive post-exposure prophylaxis with
antibiotic therapy and vaccination in accordance with standard