Drug Characteristics
  • Formulation

    600mg tablets

    Co formulated with Emtricitabine and tenofovir as ATRIPLA

  • Dose

    600mg daily

  • Side Effects

    Rash, usually in the first 2 weeks, is the most common side-effect; discontinue if severe rash/stephens johnson syndrome with blistering, desquamation, mucosal involvement or fever.

    if rash mild or moderate, may continue without interruption—usually resolves within 1 month

    Abnormal dreams , sleep disturbance fatigue and impaired concentration. 

    Patients or their carers should be advised to seek immediate medical attention if symptoms such as severe depression, psychosis or suicidal ideation occur

  • Interactions

    efavirenz has many drug interactions

    see drug interaction app

  • Renal
  • Hepatic

    can cause hepatitis  monitor liver function; avoid in moderate to severe impairment; greater risk of hepatic side-effects in chronic hepatitis B or C

  • Pregnancy

    FDA category D 

    The APR provides the best data on teratogenicity and first trimester antiretroviral therapy exposure.  There are now more than 200 prospective reports of first-trimester exposure to Efavirenz with no signal of increased risk 

  • Other Information

    Indicated as prefered first line third agent an antiretroviral treatment guidelines