Injection: 100 mg/ml

Leishmania:

Second line after liposomal amphotericin

20 mg/kg once a day (max 850 mg) for at least 20 days

Higher doses used in specialist situations

Sodium stibogluconate solution should be filtered immediately prior to use

Approximately 1–2% of patients complain of nausea, vomiting and/or diarrhoea and a slightly higher number of abdominal pain

Other common side-effects include anorexia, malaise, myalgia, arthralgia headache and lethargy

ECG changes, including reduction in T-wave amplitude, T-wave inversion and QT prolongation have been observed. (see Special Warnings and Precautions for Use in current SmPC)

Transient coughing immediately following injection was reported with varying frequency during several trials

Intravenous injection of Sodium Stibogluconate may cause transient pain along the course of the vein and eventually thrombosis of that vein

Should not be used in patients with significant renal impairment

No data

No (Limited) Human Data – Animal Studies Suggest Risk. Seek specialist advice if potential benefits to patient outweigh the possible risk to the foetus