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Formulation
Injection: 100 mg/ml
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Dose
Leishmania:
Second line after liposomal amphotericin
20 mg/kg once a day (max 850 mg) for at least 20 days
Higher doses used in specialist situations
Sodium stibogluconate solution should be filtered immediately prior to use
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Side Effects
Approximately 1–2% of patients complain of nausea, vomiting and/or diarrhoea and a slightly higher number of abdominal pain
Other common side-effects include anorexia, malaise, myalgia, arthralgia headache and lethargy
ECG changes, including reduction in T-wave amplitude, T-wave inversion and QT prolongation have been observed. (see Special Warnings and Precautions for Use in current SmPC)
Transient coughing immediately following injection was reported with varying frequency during several trials
Intravenous injection of Sodium Stibogluconate may cause transient pain along the course of the vein and eventually thrombosis of that vein
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Interactions
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Renal
Should not be used in patients with significant renal impairment
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Hepatic
No data
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Pregnancy
No (Limited) Human Data – Animal Studies Suggest Risk. Seek specialist advice if potential benefits to patient outweigh the possible risk to the foetus
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Other Information
Drug Characteristics