Drug Characteristics
  • Formulation

    Injection: 100 mg/ml

  • Dose

    Leishmania:

    Second line after liposomal amphotericin

    20 mg/kg once a day (max 850 mg) for at least 20 days

    Higher doses used in specialist situations

    Sodium stibogluconate solution should be filtered immediately prior to use

  • Side Effects

    Approximately 1–2% of patients complain of nausea, vomiting and/or diarrhoea and a slightly higher number of abdominal pain

    Other common side-effects include anorexia, malaise, myalgia, arthralgia headache and lethargy

    ECG changes, including reduction in T-wave amplitude, T-wave inversion and QT prolongation have been observed. (see Special Warnings and Precautions for Use in current SmPC)

    Transient coughing immediately following injection was reported with varying frequency during several trials

    Intravenous injection of Sodium Stibogluconate may cause transient pain along the course of the vein and eventually thrombosis of that vein

  • Interactions
  • Renal

    Should not be used in patients with significant renal impairment

  • Hepatic

    No data

  • Pregnancy

    No (Limited) Human Data – Animal Studies Suggest Risk. Seek specialist advice if potential benefits to patient outweigh the possible risk to the foetus

  • Other Information