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Formulation
Tablets: 200 mg, 400 mg
Infusion solution: 2 mg/ml
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Dose
Atypical mycobacterial infections
400 mg orally twice a day, in combination with other agents
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Side Effects
Gastrointestinal effects (nausea, vomiting, dyspepsia, abdominal pain); diarrhoea; headache; dizziness; sleep disorders; rash
Less frequently drowsiness, restlessness, confusion, convulsions. Hypersensitivity and anaphylaxis
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Interactions
Increased risk of convulsions with NSAIDS; antacids, sucralfate and iron preparations reduce absorption; warfarin effect enhanced.
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Renal
Dose in renal impairment GFR (ml/min):
10-50: Normal initial dose then reduce to 200 mg twice a day;
<10: give initial dose then reduce to 200 mg daily
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Hepatic
The excretion of ofloxacin may be reduced in patients with severe hepatic dysfunction
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Pregnancy
Human Data Suggest Low Risk
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Other Information
Drug Characteristics