Drug Characteristics
  • Formulation

    Tablets: 200 mg, 400 mg

    Infusion solution: 2 mg/ml

  • Dose

    Atypical mycobacterial infections

    400 mg orally twice a day, in combination with other agents

  • Side Effects

    Gastrointestinal effects (nausea, vomiting, dyspepsia, abdominal pain); diarrhoea; headache; dizziness; sleep disorders; rash

    Less frequently drowsiness, restlessness, confusion, convulsions. Hypersensitivity and anaphylaxis

  • Interactions

    Increased risk of convulsions with NSAIDS; antacids, sucralfate and iron preparations reduce absorption; warfarin effect enhanced.

  • Renal

    Dose in renal impairment GFR (ml/min):

    10-50: Normal initial dose then reduce to 200 mg twice a day;

    <10: give initial dose then reduce to 200 mg daily

  • Hepatic

    The excretion of ofloxacin may be reduced in patients with severe hepatic dysfunction

  • Pregnancy

    Human Data Suggest Low Risk

  • Other Information