Tablets: 200 mg, 400 mg

Infusion solution: 2 mg/ml

Atypical mycobacterial infections

400 mg orally twice a day, in combination with other agents

Gastrointestinal effects (nausea, vomiting, dyspepsia, abdominal pain); diarrhoea; headache; dizziness; sleep disorders; rash

Less frequently drowsiness, restlessness, confusion, convulsions. Hypersensitivity and anaphylaxis

Increased risk of convulsions with NSAIDS; antacids, sucralfate and iron preparations reduce absorption; warfarin effect enhanced.

Dose in renal impairment GFR (ml/min):

10-50: Normal initial dose then reduce to 200 mg twice a day;

<10: give initial dose then reduce to 200 mg daily

The excretion of ofloxacin may be reduced in patients with severe hepatic dysfunction

Human Data Suggest Low Risk