Caution when prescribing and administering amphotericin: ensure the dose administered matches the specific formulation.
Cryptococcal meningitis : 1 mg/kg IV increasing to 4 mg/kg IV once a day. A test dose should be administered prior to the first infusion (not necessary if transferring from an alternative amphotericin preparation).
Histoplasma capsulatum :
1 mg/kg IV increasing to 3 mg/kg once a day for 14 days followed by maintenance with itraconazole 200 mg oral suspension three times a day then 200 mg orally twice a day for at least 12 months.
CNS disease :
Dose up 5 mg/kg/day for 4–6 weeks.
Visceral leishmaniasis :
A total dose of 21–30 mg/kg of body weight given over 10–21 days. This differs from the regime described in the main text and specialist advice is recommended. Other fungal infections (e.g. ‘azole’ resistant candida): 1 mg/kg IV increasing to 3 mg/kg once a day, according to the infection severity. Doses should be titrated upwards from 1 mg/kg/day
Other fungal infections (e.g. ‘azole’ resistant candida): 1 mg/kg IV increasing to 3 mg/kg once a day, according to the infection severity.
Doses should be titrated upwards from 1 mg/kg/day
Reduced renal toxicity compared to conventional amphotericin B. Reduced incidence of infusion-related side effects compared to conventional amphotericin.
AmBisome ® therapy has been administered for as long as 3 months, with a cumulative amphotericin dose of 16.8 g without significant toxicity
Dose as in normal renal function
No dosage adjustment currently recommended