Drug Characteristics
  • Formulation

    Tablets: 15 mg

    Injection: 15 mg/2ml

  • Dose

    Oral dose 15- 30 mg when used with pyrimethamine

  • Side Effects

    May decrease the efficacy of cotrimoxazole (increased failure during PCP treatment has been reported)

    May diminish the effect of anti-epileptic substances: phenobarbital, primidone, phenytoin and ethosuximide and may increase the frequency of seizures

  • Interactions

    Folinic acid is contraindicated in patients with pernicious anaemia or other anaemias due to vitamin B12 deficiency. Side effects are uncommon and include fever, insomnia and agitation

  • Renal

    Dose as in normal renal function

  • Hepatic

    No dosage reduction necessary

  • Pregnancy

    Compatible

  • Other Information