Drug Characteristics
  • Formulation

    Tablets: 100 mg, 250 mg, 500 mg

    Suspension: 250 mg/5ml

    Injection: 100 mg/50ml, 200 mg/100ml, 400 mg/200ml        

  • Dose

    Treatment of gastrointestinal infections (salmonella, shigella, campylobacter):

    500 mg orally twice a day for 7–14 days (200 mg IV twice a day if the patient is vomiting)

    Salmonella septicaemia:

    Consider long-term or indefinite treatment particularly if the patient has AIDS. 250 mg twice a day for at least 3 months, following initial treatment course

    Atypical mycobacterial infections/multi-drug resistant tuberculosis:

    500–750 mg orally twice a day (as part of a combination regimen)

    Pseudomonal infections :

    500–750 mg orally twice a day or 200–400 mg IV twice a day          

  • Side Effects

    Gastrointestinal disturbances, CNS effects (dizziness, headache, insomnia, fitting, euphoria – use in caution in patients with epilepsy), transient increases in LFTs, rash, taste disturbances, transient increases in serum creatinine and urea. Tendon damage (CSM warning) and severe anaphylaxis (rare)

  • Interactions

    Antacids, sucralfate, didanosine tablets, iron, calcium and zinc supplements will all decrease absorption

    Theophylline plasma levels increased – increased risk of convulsions

    Warfarin effect enhanced          

  • Renal

    GFR 20–50: Dose as in normal renal function

    GFR <20: 50% of normal dose          

  • Hepatic

    No dosage adjustment necessary

  • Pregnancy

    Human Data Suggest Low Risk

  • Other Information

    Should not be taken at the same time of day as antacids, zinc or iron preparations

    Doses of ciprofloxacin and didanosine tablets should be separated by 2 hours